ANATOMY OF THE NAVICULOCUNEIFORM JOINT

Anatomy of the Naviculocuneiform Joint

Category: Midfoot/Forefoot; Basic Sciences/Biologics Introduction/Purpose: The naviculocuneiform (NC) joint has a role in numerous pathologies of the foot and ankle.There is little in the published literature quantifying the cartilage of the articulating surface and its unique anatomical features.The purpose of this study was to quantify and descri

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Evaluation of Sucrose Laurate as an Intestinal Permeation Enhancer for Macromolecules: Ex Vivo and In Vivo Studies

Oral delivery of macromolecules requires permeation enhancers (PEs) adaptable to formulation.Sucrose laurate (SL) (D1216), a food grade surfactant, was assessed in Caco-2 monolayers, isolated rat intestinal tissue mucosae, and rat intestinal instillations.Accordingly, 1 mM SL increased the apparent permeability coefficient (Papp) of [14C]-mannitol

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Are "Gap-Fillers" Missing Premisses?

Identifying the missing or unstated premisses of arguments is important, because their logical quality depends on them.Textbook authors regard enthymematic syllogisms (e.g., "Elvis is a man, so Elvis Neff KI5862S30G Integrated Fridge Freezer is mortal") as having an unstated premiss - the major premiss (e.g., "All men are mortal").They are said to

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Metabolomic profiling and biomarker identification for early detection and therapeutic targeting of doxorubicin-induced cardiotoxicity

BackgroundDoxorubicin (DOX) is a widely used chemotherapeutic agent known for its efficacy against various cancers, but its clinical application is often limited by its cardiotoxic effects.The exact mechanisms of DOX-induced cardiotoxicity remain unclear, requiring further investigation.Early diagnosis is essential to enhance the quality of life an

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